Instructor resources 2

This page is a continuation of instructor resources.

Fad diets
Marijuana
Genetically Modified Organisms (GMOs)
Stem cells
Art and Science
Climate change
3D printing of body parts



Topic: Fad diets

Course relevance: Cell chemistry, nutrition, health

Summary: Dieting is rampant in our society. The entertainment industry and fashion advertising popularize stick figure women, to make people feel inadequate or insecure so they buy advertised products. One product advertised like crazy is fad diets. There are hundreds of diets. Fad diets are popular short term weight loss diets of the day, which often suggest completely opposite eating regimes to one another. They more often than not result in weight gained back after completing the diet, and can even be dangerous because they eliminate certain nutrients, resulting in malnutrition. Fad diets can be spotted easily because they often promise very quick weight loss, warn against some component of food & eliminate it, and cost a lot of money. Further, there is little or questionable research to validate the diet. Some popular and potentially dangerous diets are: the 4-hour body, blood-type, HCG, south beach, Atkins, Bernstein, Zone, lemon detox, Paleolithic, and the Dukan diet. Other strange and more dangerous diets include the cabbage soup diet, apple cider vinegar diet, acai berry diet, and the tapeworm diet. As an example, the HCG diet involves a hormone (human chorionic gonadotropin) that has nothing to do with diet and is not approved for that purpose in Canada. Some diets may be specific for diseases – such as gluten-free diets which are meant for those with celiac disease, and other medical conditions, but not for general weight loss. Some diets turn out to have efficacy in treatment of certain conditions, such as the Atkins diet, which is used with epilepsy patients. There are many sound recommendations for safe and healthy eating habits, which are particularly effective when combined with regular exercise, adequate water intake and adequate sleep. Any diet one is contemplating should be researched thoroughly, for the safety of the diet and also whether the diet is compatible with the physical conditions of the dieter.

Background material:

How stuff works site on the 10 most absurd fad diets:
http://health.howstuffworks.com/wellness/diet-fitness/weight-loss/10-fad-diets.htm

Losing weight without fad diets:
http://www.webmd.com/diet/guide/the-truth-about-fad-diets

Winter. L. 2014. Dr. Oz admits ‘miracle’ diet products he advocates are pseudoscience. FULL ARTICLE

Videos

TED talk Sandra Aamodt. Why dieting doesn’t usually work
http://www.ted.com/talks/sandra_aamodt_why_dieting_doesn_t_usually_work

Science journal articles

Foster et al. 2003. A randomized trial of a low-carbohydrate diet for obesity. N. Engl. J. Med. 348:2082-2090
http://www.nejm.org/doi/full/10.1056/NEJMoa022207

Cole, L.A. 2010. Illicit use of HCG in dietary programs and use to promote anabolism, Chapter 17 from Human Chorionic Gonadotropin. Elselvier. SUMMARY

Pietzak, M. 2012. Celiac disease, wheat allergy, and gluten sensitivity. When gluten-free is not a fad. JPEN 36(1): 685-755 SUMMARY

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Topic: Marijuana
800px-Hemp_flowers

Course relevance: Chemistry, alternative medicine, pathophysiology

Summary: Marijuana (Cannabis sativa) is a fascinating plant. As with many plants, it produces antibiotics and anti-fungal substances collectively known as cannabinoids, THC (delta-9-tetrahydrocannabinol) is probably the most potent, and its function appears to be protecting the plant from UV radiation. In humans, cannabinoids interact with receptors in the central nervous system and immune system of the body, and are thought to be useful in treating various ailments, such as glaucoma, pain, nausea, muscle spasms and loss of appetite. THC or synthetic THC mimics endogenous substances found in the body, and binds to their receptors. For example, the drug dronabinol, a synthetic THC, can increase appetite by binding to receptors in the hypothalamus known to stimulate appetite. There are some studies showing reduction in pain with marijuana use of people with neuropathic pain. Marijuana in the treatment of glaucoma to lower intraocular pressure appears to work, but for a very short time. There are sporadic studies on the efficacy of marijuana treatment for epilepsy, and more studies are underway. There are inconsistent studies in the treatment of MS with the drug. There is also some preliminary research into treatment of autoimmune diseases. Studies investigating the drug’s use for tumour treatment have shown some cell growth control in mice, and human trials may be underway. In conclusion, there are very many unanswered questions with respect to the treatment of diseases with marijuana. Claims that it is a “cure” for this or that are unsubstantiated and irresponsible. As with any drug used for medicinal purposes, side effects must be taken into account, such as effects on fertility, competition with other chemicals in the body, and possible links to psychological disorders.
Longer report IFLS marijuana PDF

Background material:

Cotter, J. 2009. Efficacy of crude marijuana and synthetic delta-9-tetrahydrocannabinal as treatment for chemotherapy-induced nausea and vomiting: a systematic literature review. Oncology Nursing Forum 36(3). SUMMARY

Science journal articles

Brisbois et al. 2010. Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. Annals of Oncology. 22(9). 2086-2093

http://annonc.oxfordjournals.org/content/22/9/2086

Ware. M.A. et al. 2008. A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting. Therapeutics and Clinical Risk Management. 4(1): 99-107

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503671/
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Topic: GMOs – Genetically modified organisms, vs. transgenics

Course relevance: Genetics, biotechnology, synthetic prostheses

Summary: First of all, different sources use the terms GMO and transgenics in different ways. Really, a GMO or genetically modified organism, is any organism that has had its DNA altered in some way. Humans have been doing this for tens of thousands of years by artificial selection and crossbreeding. All food products that humans get from the market are genetically modified. In the past animal and plant mutations were chosen by humans that would not have persisted in the wild. For humans, however, it meant a sweeter, larger, better looking food product. A transgenic organism, on the other hand, is an individual of one species that has had DNA from another species inserted into its own DNA. This is known as genetic engineering. These have been around for thirty years or so. Nowadays this is what many people are calling GMOs. The question is: are they safe for humans? Tough question to answer, unless of course you go directly to scientific literature. I found an excellent meta-study by Niciolia et al (2013), which discovered no negative impact of genetically engineered crops and biodiversity, gene flow, or as food for humans or feed for animals. MTC

Background material

Videos

Science journal articles

Nicolia et al. 2013. An overview of the last 10 years of genetically engineered crop safety research. Critical Reviews in Biotechnology. Early Online: 1-12

http://www.geneticliteracyproject.org/wp/wp-content/uploads/2013/10/Nicolia-20131.pdf

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Topic: Stem cell research

Course relevance: Cell biology, pathophysiology

Summary: Stem cells have been prevalent in the news for the past few years, and progress in the field is happening in leaps and bounds. There are adult stem cells and embryonic stem cells. A stem cell is non-functional and undifferentiated cell. A totipotent cell is one that could eventually be any cell in the body. The zygote and early embryonic cells are totipotent. A pluripotent cell may become several different types of cells, such as red and white blood cells. A neural pluripotent stem cell can become a neuron, astrocyte or oligodendrocyte. A unipotent cell can only differentiate into one type. In research, stem cells may be used from embryos or adults. The less differentiated a cell is, the more likely it will be compatible between people. Adult cells can also be induced to regress back to being stem cells (Induced pluripotent stem cells). Stem cells are used for a variety of reasons. One is to replace or replenish cells in an ailing individual. This is done with ALS patients with a variety of stem cells; neural, bone marrow and hematopoietic (Meamar et al 2013). Stem cells have also been used to replace retinal pigment epithelium in persons with age-related macular degeneration (Carr et al 2013). There seems to be potential in the application of stem cell therapy in respiratory diseases as well (The authors 2013). Stem cell therapy is also used to replace cardiac tissue with myocardial infarction, and biological pacemakers are being explored (Chauveau et al 2014). The hurdles to stem cell therapy is the reaction of the recipient’s immune system, and the possibility of tumour formation.

Background material:

University California stem cell program: http://stemcells.ucsd.edu/

Videos

10 talks on the future of stem cell medicine: http://blog.ted.com/2012/09/13/10-talks-on-the-future-of-stem-cell-medicine/

NOVA ScienceNow video: Stem cells (in class video, not available online)

Science journal articles

Meamar et al. 2013. Stem cell therapy in amytrophic lateral sclerosis. Journal of clinical neuroscience 20,

Carr et al. 2013. Development of human embryonic stem cell therapies for age-related macular degeneration. Trends in Neurosciences 36 (7)

The Authors. 2013. The burden of lung disease: The need for stem cell therapy. A review series prologue. Respirology 18, 393-396

Chauveau et al. 2014. Stem cell-based biological pacemakers from proof of principle to therapy: a review. Cytotherapy, 2014; 16: 873-880.

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Topic: Art and science

Course relevance: Illustrating science, visual enhancement

Summary: Science and art are not mutually exclusive. Sure, art students feel forced to take a science elective, but science can be quite creative and beautiful. There are two ways in which art fits into science. One is in the illustration of science which has been around since Aristotle…science would be lost without it. With today’s technology, artistic renditions of science, such as the replication of DNA, is amazing and informative. The other benefit of art for science is to engender appreciation from non-scientists. As science instructors and students, it is up to us to education the general public on scientific concepts. Non-scientists are more likely to listen and appreciate esthetically-pleasing reports. The Beatty Biodiversity Museum at UBC has incorporated artists’ drawings along with some of their specimens. It adds a personal touch. Indeed, if you are contemplating a career in botany, one of the most rewarding activities is to draw plants with pointillism or watercolours.

Background material:

From: ideas.ted.com – Stunning, psychedelic images where art and science collide.

oefner_black_hole_07
Videos

TED talk: Drew Berry – Animations of unseeable biology (excellent DNA replication animation)
https://www.ted.com/talks/drew_berry_animations_of_unseeable_biology

I like this quote from the 2011 TED handbook:

“A Universe of Possibility. Grey Infused By Color. The Invisible Revealed. The Mundane Blown Away By Awe.”

And this venn diagram:

2011-03-08-Science_Wonder_Art

And this picture of diatom art from: http://rebloggy.com/post/art-sewing-marine-biology-victorian-art-hobbies-microscopic-quilting-diatoms-dia/69047688451

diatom art
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Topic: Climate change

Course relevance: global environment, ecology, biodiversity

Summary: Climate change, incredibly, is still being debated in some circles. The main reason is that people tend to throw out the vast majority of evidence for climate change (warming earth temperatures which has been around for years) in favour of one or two naysayers. And the reason for that is that the naysayers get about as much media attention as the climatologists. To put the issue into perspective, John Oliver offers a realistic view of science communication (Oliver 2014) If you have any doubts, watch the video. Fortunately, the vast majority of the population has accepted the reality of climate change and now when one researches the question, the science articles are not on evidence for climate change, because that has been established, but on the impacts of climate change and solutions and strategies to deal with it. There are strategies to try and alleviate further global warming by cutting CO2 and other emissions in the atmosphere, and strategies to deal with the effects of global warming such as flooding due to rising sea levels, impacts on agriculture, ocean acidification (one of the most serious), air quality, and desertification. Most importantly, this is the time to focus on solutions, and there are many. For example, Germany produces up to 50% of its energy using solar panels. Sainsbury’s in the UK uses food waste (organic material that can’t be used by foodbanks or animal feed) to produce energy (biogas plants use the methane produced by rotting food for energy). Wind farms are being built all over the world, on land and offshore, to produce energy.

Background material

It is thought that this much space is what is needed to supply energy to Germany (the smallest red square), Europe (the second largest), and the world (the largest red square).

space for solar energy
Videos

Oliver, John. 2014. Last week tonight with John Oliver: climate change debate

Science journal articles

Lemieux, C.J. et al. 2014. From science to policy: the making of a watershed-scale climate change adaptation strategy. Environmental Science & Policy 42, 123-137

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Topic: 3D printing of body parts

Course relevance: Technology in medicine

Summary: 3D printers have been around for about 20 years. It is a technology that is advancing in a similar manner to the regular paper printers we are familiar with. The term 3D printer is used, although it’s really a tiny manufacturing plant. Instead of putting ink on paper two-dimensionally, a 3D printer extrudes materials to build a 3D object in layers. The materials used are materials that can be powered for laser binding, or melted for extrusion. Mostly, plastic filaments are used. 3D objects are printed using a file of the object usually created with CAD software. One company offering the printers is 3D Printers Canada. An entry level hobbyist machine would be around $1000, but the real heavy duty ones can be more than $600,000. People print toys and gadgets, figurines, and even parts of houses. Of interest is 3D printed body parts, sometimes known as bioprinting. Some parts that have been printed are: prosthetic limbs, skull, hip replacements, pelvis, and eyes.

Longer report: http://www.iflscience.com/technology/3d-printed-body-parts-go-mainstream

Background material:

3D printing explained simply:

http://3dpreport.com/3d-printing-101/

Videos

http://www.explainingthefuture.com/video_bioprinting.html

Body parts made with 3D printers:
Daniel Omar with his prosthetic arm
Not impossible/project Daniel. Daniel Omar with the prosthetic arm.

skull2_3
UMC Utrecht

eyes
Fripp Design/Manchester Metropolitan University

bionicear_9245_preferred-by-mcm_400
Frank Wojciechowski, Princeton Unveristy. The “bionic ear”

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